منابع مشابه
A review of post-GWAS prioritization approaches
In the recent decade, high-throughput genotyping and next-generation sequencing platforms have enabled genome-wide association studies (GWAS) of many complex human diseases. These studies have discovered many disease susceptible loci, and unveiled unexpected disease mechanisms. Despite these successes, these identified variants only explain a small proportion of the genetic contributions to the...
متن کاملtranSMART Supports a Post-GWAS Data Coordinating Center
The University of Michigan Comprehensive Cancer Center Informatics Core, in cooperation with Recombinant Data Corp, has implemented the open-source tranSMART application (http://www.transmartproject.org/) to support data management and analysis for the Colorectal Transdisciplinary Study (CORECT) Consortium coordinating center. CORECT is a post-GWAS consortium study of the genetic and epidemiolo...
متن کاملPGA: post-GWAS analysis for disease gene identification.
Summary While the genome-wide association study (GWAS) is a powerful method to identify disease-associated variants, it does not directly address the biological mechanisms underlying such genetic association signals. Here, we present PGA, a Perl- and Java-based program for post-GWAS analysis that predicts likely disease genes given a list of GWAS-reported variants. Designed with a command line ...
متن کاملThe post GWAS era: strategies to identify gene-gene and gene-environment interactions in urinary bladder cancer
Bladder cancer is a smoking-and occupational exposure-related disease with a sub-Both family studies and large genome-wide association analyses support a polygenetic basis for uri-nary bladder carcinomas, mainly because there is no evidence for a major gene (Aben et al. Several of these moderate-risk variants, especially those categorized as phase II metabolism genes, have been shown to modulat...
متن کاملGwas
That’s interesting. Care to elaborate? Part of the problem in trying to make a movie about real animals is that they aren’t actors. You can write a script — and there was one — but the chimps didn’t always follow it! So, like a good field worker, one had to adapt as the film footage came in and the story line changed. In this day and age of global warming, disease pandemics, and the like, it’s ...
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ژورنال
عنوان ژورنال: Genomics & Informatics
سال: 2011
ISSN: 1598-866X
DOI: 10.5808/gi.2011.9.1.001